The Physiology of EMESIS.

"The physiology of emesis has been studied for several hundred years, focusing on the different centres involved and the mechanics of expulsion. The vomiting centre receives inputs from various emetic detectors such as the gut, the vestibular labyrinths and the chemoreceptor trigger zone. Emesis is a common disabling effect in motion sickness, postoperative conditions and in radio - and chemotherapy."(¹)

What are we doing about it? Most drugs currently used against motion sickness were identified over 30 years ago (²).

(²) Wood CD, Graybiel A. Evaluation of 16 antimotion sickness drugs under controlled laboratory conditions. Aerospace Med, 1969;39:1341-4.

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Nausea and vomiting - "emesis"

The word "emesis" is used by the medical and scientific worlds to describe the physical act of being sick.
For many years the medical world has known that there is a vomiting control centre within the brain and that at the same time that the vestibular system (the inner ear) has a direct part to play in the act being sick as a result of "travel" or motion sickness.

Now there is a large body of clinical evidence that the neurological pathways of emesis are similar – irrespective of the cause of the symptoms. In other words, find a solution for travel sickness and pregnancy sickness, and it is likely to work for a variety of conditions where emesis is a resultant.

Similarity of symptoms

Nevasic works directly on the balance receptors in the vestibular system and therefore addresses the symptoms - not the cause of emesis. It is the vestibular system that is our gateway to the symptoms. In the report abstracts below there are named conditions such as motion sickness, morning sickness, radio and chemotherapy - all with a common theme - nausea and vomiting, or emesis. Just follow the links if you’d like to know more.

Relief

Nevasic has been proven to be highly effective in effective in easing and stopping the symptoms of nausea and vomiting- and there is no reason why Nevasic may not provide relief from emesis arising from conditions or treatments listed below, without the complications and fears of side effects or contra-indications.

The Physiology of EMESIS.(¹)

"The physiology of emesis has been studied for many years, focusing on the different centres involved and the mechanics of expulsion. The vomiting centre receives inputs from various emetic detectors such as the gut, the vestibular labyrinths and the chemoreceptor trigger zone. Emesis is a common disabling effect in motion sickness, postoperative conditions and in radio - and chemotherapy."

Courtesy of Medscape / Medline:-

Maternal susceptibility to nausea and vomiting of pregnancy:

Nausea and vomiting of pregnancy shares many characteristics with motion sickness, a vestibular dependent phenomenon. A number of physiologic changes that occur in normal pregnancy are also known to accompany nausea and vomiting in patients with motion sickness and certain vestibular disorders. This chapter summarizes some shared features of both phenomena. The unmasking of subclinical vestibular disorders may account for some cases of hyperemesis gravidarum. Hormonal effects on neurotransmitter function may also play a role in nausea and vomiting of pregnancy and in some vestibular disorders; however, the specific neural mechanisms of nausea and vomiting have not been identified. Until the neurochemical processes underlying these phenomena are understood, prevention and management will remain in the domain of astute, but so far limited, clinical observation (³)

(¹) MEDLINE Indexing Date : 199706
Publication Type : JOURNAL ARTICLE; REVIEW (141 references); REVIEW, TUTORIAL
Unique NLM Identifier: 97180566
Journal Code : M
To see this review go to Medscape then select Medline, enter the following line in the search by author field.
Veyrat-Follet C; Farinotti R; Palmer JL